Zofran is a medication that is used to stop nausea and vomiting brought on by cancer drug treatment and radiation therapy. It’s also used treat and prevent nausea and vomiting experienced post surgery. How the drug works is by blocking the body’s natural substance, serotonin, that is responsible for vomiting. Unfortunately, Zofran was being marketed further by its creators GlaxoSmithKline as an anti-nausea drug for women experiencing nausea and vomiting (NVM) during pregnancy.
There have been studies conducted to see if this use of Zofran on pregnant women is safe for their developing babies. The studies have come back with results showing that Zofran is likely a causal agent for certain birth defects such as cleft palate and congenital heart defects when Zofran was used in the first three months of the fetus’ development. One of those studies called the Andersen Study, conducted in August 2013, analyzed data from over 900,000 pregnancies. Of that number 1,248 of the expectant moms were given Zofran to alleviate serious morning sickness and found that 4.7 per cent of the babies born of those women had a congenital heart defect. The overall conclusion of the study was that moms who used Zofran while pregnant increased the chance of their newborn being born with a congenital heart defect, babies were two to four times more at risk to be born with a septal cardiac defect, and that all in all there was a 30% prospect of a baby having deformations. Needless to say, there have been lawsuits filed that affirm these findings.
Newborn Birth Defect Stats In Oklahoma
As of the latest population records, Oklahoma’s population is recorded as 3,878,051. Out of that number the most densely populated cities are:
- Oklahoma City- 620,602 population
- Tulsa- 399,682 population
- Norman- 118,040 population
- Broken Arrow- 104,726 population
- Lawton- 97,017 population
The Oklahoma Birth Defects Registry (OBDR) reports that of the 53,000 babies born in Oklahoma each year, more than 1,900 (3.7%) will be born with a birth defect or other serious condition. For all of America, it is approximated that for every 33 newborns one is born with some kind of birth irregularity. As Zofran was introduced to the American market in 1991 it became wildly popular as the drug for mitigating nausea and vomiting of pregnancy (morning sickness) and led to its 99 per cent market dominance in 2005.
We used this information as well as the averaged exposure ratios recognized in the various clinical studies completed, and estimated that an approximate 1,918 newborns in Oklahoma were born with a defect that was caused by the existence of Zofran in utero.
What Are The Cleft Palate & Congenital Heart Defects Cases Linked To Zofran In Oklahoma?
Accounting for the Oklahoma population of 3,878,051 we have probable figures of 364 births that are some type of cleft palate and 1,554 that were congenital heart defects or hole in the the heart cases, that were likely caused by the presence of Zofran in utero. We further calculated the number of probable cases in Oklahoma’s five most densely inhabited cities:
- Oklahoma City- 341 probable birth irregularities with almost 58 cleft palate, and 283 hole in the heart abnormalities
- Tulsa- 237 probable birth irregularities with almost 37 cleft palate, and 200 hole in the heart abnormalities
- Norman- 105 probable birth irregularities with almost 11 cleft palate, and 94 hole in the heart abnormalities
- Broken Arrow- 99 probable birth irregularities with almost 10 cleft palate, and 89 hole in the heart abnormalities
- Lawton- 95 probable birth irregularities with almost 9 cleft palate, and 86 hole in the heart abnormalities
Reported Unfavorable Side Effects Of Taking Zofran
As already mentioned in this article, many clinical studies have been conducted by the medical communities from around the world, that have seen first hand accounts of the effects of Zofran on an unborn baby. But, this has not been enough to see GSK claim responsibility of the unfavorable effects Zofran has on an unborn child. Despite their denial, reports that have been filed against GSK have seen some of the following defects as being the result of taking Zofran while pregnant:
- Hole in the heart defects
- Kidney malformations
- Webbed toes
- Low set ears
- Facial dysmorphia
- Cleft palate
- Talipes equinovarus
A study by CDC and Sloan Epidemiology discovered that there was twice the chance of a baby being born with a cleft palate in situations where the mother had taken Zofran for morning sickness in the first few months of her pregnancy. Read more about this study here.
Oklahoma Parents Making Contact For Zofran Lawsuits Information
A number of law firms located in different parts of the country are sponsors of this website. ZofranLegal.com was created with the intention of supplying up to date information about the Zofran litigation. Albeit, our attorneys are not licensed to practice law in the state of Oklahoma, we are licensed to practice law in Delaware where we have offices as well. Delaware is also the state where GSK has its HQ. What all this means is that we are able to fully represent your case when it is filed in Delaware state. For our office information click here.
Your case can either be filed in Delaware where we can represent it or at a different site, or we may deem it appropriate to file your case in Oklahoma with the aid of our trusted local counsel. If you would like to know more about how to file, please contact us. Our Zofran advocates are available to speak and answer your questions at any time. Find out more about our Zofran lawyers, here.
Websites For Oklahoma Parents Researching Cleft Palate & Congenital Heart Abnormalities
Cleft Smile.org: http://www.cleftsmile.org/state-resources/oklahoma-resources/
Oral Facial Surgery Center: http://www.oralfacialsurgeons.com/patient-information/cleft-team.asp
Cleft Palate Foundation: http://www.cleftline.org/parents-individuals/team-care/state-listings-o/
Oklahoma Birth Defects Registry: http://www.ok.gov/health/Child_and_Family_Health/Screening,_and_Special_Services//Oklahoma_Birth_Defects_Registry_/
Integris Baptist Medical Center: http://integrisok.com/screening-heart-defects