Zofran is an oral medication that has been proven to be effective medication for the treatment of nausea and vomiting. Zofran’s use is also referred to as an antiemetic. Antiemetic drugs are said to typically prevent motion sickness and side effects from chemotherapy due to cancer treatment. Zofran works as a 5-HT3 (serotonin) receptor antagonist, which means it blocks the vomit reflex by restricting 5-HT3 receptors in the vomiting center.
Zofran was manufactured by GlaxoSmithKline (GSK) and was approved by the Food and Drug Administration in 1991 for the very specific purpose of alleviating nausea and vomiting (NVM) in patients going through chemotherapy and radiation therapy, and preventing postoperative NVM. Click here for more information about what Zofran was originally approved for. In all this Zofran was never approved for use in pregnant women experiencing Hyperemesis gravidarum (HG), which is extreme and relentless nausea and vomiting during pregnancy. However, the manufacturers of Zofran went beyond the drug’s original use and started marketing it as an ‘off-label’ drug for use in pregnant women suffering from HG. As a result of this misleading marketing, Zofran was ingested by pregnant women in need of relief from HG but unfortunately, ended up giving birth to children with deformities such as cleft palate and congenital heart defects also known as ‘hole in the heart’.
Numerous lawsuits have since been filed against the manufacturer (GSK) stating that Zofran was the cause of a baby being born with irregularities.
Number Of Birth Irregularities In Utah
The Utah Department of Health, goes on record saying 1 in 50 births in Utah is afflicted by some type of birth irregularity. The US Centers for Disease Control (CDC) gauges a one in 33 chance of every live birth resulting in an irregularity. The 2014 census estimation stands at 2,942,902. Going by that figure it is estimated that 1,480 resulted in an irregularity.
Birth irregularities are not uncommon and the genesis of them can range from genetic issues to problematic drugs taken during pregnancy. Our Zofran attorneys have evaluated the state of Utah in an effort to figure out the number of possible birth defect cases using existing information from clinical studies that determined the probability of varieties of irregularities caused by Zofran, the overall population, and the Utah birth rates.
The data for Utah’s five biggest cities breaks down as follows:
- Salt Lake City- population 190,884
- West Valley City- population 134,495
- Provo- population 114,801
- West Jordan- population 110,920
- Orem- population 91,781
Possible Cleft Palate and Hole In The Heart Abnormalities In Utah And Its Biggest Cities
Adopting Utah’s population of 2,942,902 we determined a possible 276 birth irregularities that were a form of cleft palate and possibly 1,204 that were a form of hole in the heart (congenital heart defects) that were brought about by the ingestion of Zofran in the early stages of pregnancy.
Appropriating Utah’s biggest city populations, these birth irregularities stats come up with the following results:
- Salt Lake City- 140 birth irregularities with almost 18 cleft palate, and 122 hole in the heart abnormalities
- West Valley City- 113 birth irregularities with almost 13 cleft palate, and 100 hole in the heart abnormalities
- Provo- 104 birth irregularities with almost 10 cleft palate, and 94 hole in the heart abnormalities
- West Jordan- 102 birth irregularities with almost 10 cleft palate, and 92 hole in the heart abnormalities
- Orem- 93 birth irregularities with almost 9 cleft palate, and 84 hole in the heart abnormalities
Birth Defects And Other Negative Effects That Have Been Documented So Far
We stated earlier that clinical studies have been undertaken that have linked Zofran with a heightened prospect of a baby being born with birth irregularities like hole in the heart, cleft palate and more. Even with these studies that link Zofran to unfavorable birth defects, GSK remains indifferent that their drug is to blame. However, there have been filed lawsuits that have alleged that Zofran was the cause of these negative effects:
- Heart murmurs
- Kidney malformations
- Webbed toes
- Low set ears
- Bicuspid aortic stenosis
- Facial Dysmorphia
- Cleft Palate
Utah Families Get In Touch With ZofranLegal.com About Zofran Proceedings
ZofranLegal.com is subsidized by various law firms for the primary reason of supplying constant information about the Zofran lawsuit. Our Zofran representatives are not licensed to practice law in all of Utah. However, we are licensed to practice law and hold offices in Delaware state. GSK houses its headquarters in Delaware, therefore, we are able to serve you in your Zofran case. For our Delaware contact information click here.
Hundreds of phone calls and contact forms hailing from Utah based families affected by Zofran in the early stages of pregnancy, have been in touch with us already. We are also very aware that everyone’s situation and case is going to be different, therefore, we may advise you to file a Zofran case in Delaware state or a more appropriate venue, or even local Utah counsel to work on your case.
Please feel free to contact us about any questions you may have regarding your Zofran litigation. Our attorneys are here to speak with you at any time of the day. Click here to know more about the Zofran advocates.
Beneficial Utah Information About Cleft Palate And Hole In The Heart
Intermountain Primary Children’s Hospital:
Utah State University:
University of Utah Health Care:
Utah Department of Health:
Utah’s Indicator- Based Information System for Public Health: